Ammonia → HCID 22228384, compound
Reaction equation
CO[N:3]=[C:4]1[C:12]2[C:7](=[CH:8][C:9]([N:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.N.[H][H]>[Pd].CO>[N:13]1([C:9]2[CH:8]=[C:7]3[C:12](=[CH:11][CH:10]=2)[CH:4]([NH2:3])[CH2:5][CH2:6]3)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
5-Piperidin-1-ylindan-1-one O-methyloxime (2.95 g, 12 mmol), 10% palladium on carbon (1.45 g), and 20% ammonia in methanol (80 ml), were placed in a Parr apparatus, which was charged with hydrogen to 60 psi. The mixture was shaken for 1 hour at ambient temperature and filtered. The filtrate was removed under vacuum to provide the title compound which was used without further purification.
Workup
- filtrationfiltered
- customThe filtrate was removed under vacuum
Sources & evidence
- ORD record
- ord-1b803bc2fcf743539c676f34dd52b808
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071762B2
Reaction notes
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