8-Ethenyl-7-fluoro-2-(methoxy)-1,5-naphthyridine → 8-Ethyl-7-fluoro-2-(methyloxy)-1,5-naphthyridine

Participants

Reaction Steps

8-Ethenyl-7-fluoro-2-(methoxy)-1,5-naphthyridine (for a synthesis see WO2004/058144 Example 53(h)) (1.0 g, 4.90 mmol) was stirred in EtOH (50 ml) with 10% palladium on carbon (0.2 g) and the resulting suspension was hydrogenated under 1 atmosphere of hydrogen pressure for 3 h. The mixture was filtered with suction through celite and the solids were washed with MeOH (500 ml). The combined filtrate plus washings were concentrated to give the title compound as a clear oil (1.045 g, 103%).

Provenance & Evidence