Methyl iodide → 2-methyl-4-phenylmethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido-[3,4-e]pyrimidin-5(8H)-one

HRID 65701

Reaction equation

HRID 65701 reaction equation
[CH3:1][C:2]1[CH:18]=[C:5]2[NH:6][C:7](=[O:17])[C:8]3[CH:13]=[N:12][C:11]4[NH:14][N:15]=[CH:16][C:10]=4[C:9]=3[N:4]2[N:3]=1.C(N1C2N=CC3C(=O)NC4N(N=C(C)C=4)C=3C=2C=N1)C.[CH2:39](I)[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1.CI>>[CH3:1][C:2]1[CH:18]=[C:5]2[N:6]([CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:7](=[O:17])[C:8]3[CH:13]=[N:12][C:11]4[NH:14][N:15]=[CH:16][C:10]=4[C:9]=3[N:4]2[N:3]=1

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 12098Benzyl iodideHCID 1357053822-methyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-oneHCID 1358394108-ethyl-2-methyl-4-H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

Product 1

HCID 227574882-methyl-4-phenylmethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido-[3,4-e]pyrimidin-5(8H)-one

Procedure

By substituting the 2-methyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one of Example 8 for the 8-ethyl-2-methyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]-pyrido[3,4-e]pyrimidin-5(8H)-one and benzyl iodide for the methyl iodide in the procedure of Example 1 c, 2-methyl-4-phenylmethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido-[3,4-e]pyrimidin-5(8H)-one is obtained.

Sources & evidence

ORD record
ord-d2dc3be9b1354793b2fdf34afec77b1f
Source dataset
uspto-grants-1978_12
Patent number
US04128645

Linked notes

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