Sodium Hydroxide → HCID 178518977, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=O)=[C:6]([NH:8][C:9]([NH2:11])=[O:10])[CH:7]=1.[OH-].[Na+]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N+:12]([O-:14])=[N:11][C:9](=[O:10])[NH:8][C:6]=2[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of N-(5-chloro-2-nitrophenyl)urea (1.558 g, 7.230 mmol) in an aqueous NaOH solution (4.34 g NaOH in 15 ml water) was heated at reflux for 0.5 h before cooling and treatment with water (100 ml). The mixture was then heated to reflux again and the hot mixture filtered through a Buchner funnel. The filtrate was then acidified with conc. HCl and the resultant solid was filtered, washed with water (20 ml) and dried in vacuo to give the desired product (700 mg, 49%).
Workup
- temperaturewas heated
- temperatureat reflux for 0.5 h
- temperaturebefore cooling
- temperatureThe mixture was then heated
- temperatureto reflux again
- filtrationthe hot mixture filtered through a Buchner funnel
- filtrationthe resultant solid was filtered
- washwashed with water (20 ml)
- customdried in vacuo
Sources & evidence
- ORD record
- ord-c78787aec78f4aa7ab41a3355e617f86
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071592B2
Reaction notes
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