(3-Methoxy-4-methylphenyl)methanol → 3-Methoxy-4-methylbenzaldehyde
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][OH:11])[CH:6]=[CH:7][C:8]=1[CH3:9]>[O-2].[Mn+2].ClCCl>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([CH:4]=1)[CH:10]=[O:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
At ambient temperature, 36.35 g (238.8 mmol) of (3-methoxy-4-methylphenyl)-methanol and 207.6 g (2.4 moles/10 eq.) of manganese oxide are mixed into 730 mL of dichloromethane. Stirring is carried out at ambient temperature overnight, followed by filtration over Celite and rinsing with dichloromethane. After concentration of the combined filtrates, the desired product is obtained.
Workup
- filtrationfollowed by filtration over Celite
- washrinsing with dichloromethane
Sources & evidence
- ORD record
- ord-96a21904e825421cb070c88fd0d19996
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08076325B2
Reaction notes
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