HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Azidomethyl)-2-methylpyrimidine → (2-Methylpyrimidin-5-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Azidomethyl)-2-methylpyrimidine | HCID 54595022 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (2-Methylpyrimidin-5-yl)methanamine | HCID 21294601 | — |
Reaction Steps
A mixture of 5-(azidomethyl)-2-methylpyrimidine (2.0, 13.4 mmol) in ethyl acetate (100 mL), and 10% Pd—C (4.0 g) was stirred under H2 (1 atm) for 1.5 hr. The catalyst was filtered off and filtrate was concentrated in vacuo to afford a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08076345B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-b72392e4d85f48d1980ff7238dcb0187 |
| Source note | uspto-grants-2011_12 |