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Acetone → HCID 178484388, compound

HRID 658124
Notes
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Reaction equation

HRID 658124 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].CC(C)=O.O.[C:15]([OH:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>CC(C)=O.O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:15]([O-:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 180AcetoneHCID 743Glutaric AcidHCID 962WaterHCID 178484382HCID 178484382, compound

Product 1

HCID 178484388HCID 178484388, compoundYield 143.9%

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)
Solvent

Conditions

Temperature
10 °C

Procedure

9.75 g (2.5 molar equivalents) of the metformin free-base was stirred in a mixed solution of 112.5 ml of acetone and 5 ml of water at 40° C., and a solution of 3.98 g (1 molar equivalent) of glutaric acid in acetone-water was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 11.24 g (yield: 95.3%) of metformin glutarate.

Workup

  1. filtrationThe produced crystal was filtered
  2. customdried in hot air

Sources & evidence

ORD record
ord-b1476a9df4084ce29a100deb4b1d44bd
Source dataset
uspto-grants-2011_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08076377B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes