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Adipic Acid → HCID 178484387, compound

HRID 658128
Notes
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Reaction equation

HRID 658128 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].[C:13]([OH:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:13]([O-:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 196Adipic AcidHCID 6344DichloromethaneHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Product 1

HCID 178484387HCID 178484387, compoundYield 119.1%

Reagents, catalysts & solvents 1

HCID 702Ethanol
Solvent

Procedure

10.00 g of metformin hydrochloride, 2.40 g of sodium hydroxide and 2.20 g of adipic acid were stirred in 150 ml of ethyl alcohol at 70° C., and then methylene chloride was added thereto. Then, the produced inorganic salt was filtered, and ethyl acetate was added to the filtrate. The produced crystal was filtered and dried in hot air, thus obtaining 4.90 g (yield: 80.5%) of metformin adipate.

Workup

  1. filtrationThen, the produced inorganic salt was filtered
  2. additionethyl acetate was added to the filtrate
  3. filtrationThe produced crystal was filtered
  4. customdried in hot air

Sources & evidence

ORD record
ord-6a57b952a08b47e2ab3e40695d305e26
Source dataset
uspto-grants-2011_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08076377B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes