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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658772Generated: October 26, 2026

3-((tert-Butyldimethylsilyl)oxy)-4-methoxybenzaldehyde → Methyl 1-(3-(tert-butyldimethylsilyloxy)-4-methoxybenzylamino)cyclopropanecarboxylate

https://huagongshe.com/reaction/658772

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-((tert-Butyldimethylsilyl)oxy)-4-methoxybenzaldehydeHCID 359558—
ReactantMethyl 1-aminocyclopropane-1-carboxylate hydrochlorideHCID 12760695—
ProductMethyl 1-(3-(tert-butyldimethylsilyloxy)-4-methoxybenzylamino)cyclopropanecarboxylateHCID 5952436879%

Reaction Steps

Prepared as in Example 12-1b from 3-(tert-butyldimethylsilyloxy)-4-methoxybenzaldehyde (Example 12-2c) and methyl 1-aminocyclopropanecarboxylate hydrochloride. Yield 79%. MS 366 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08076491B2
Source datasetuspto-grants-2011_12
ORD IDord-79a7e201ec9e48cba5aa12f0cceae462
Source noteuspto-grants-2011_12