Methanol → 3-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid

Participants

Reaction Steps

The ester (33) (41 mg, 0.12 mmol) was hydrolysed using Method C, except that MeOH (3 mL), THF (3 mL) and 1M NaOH (5 mL) were used, and the reaction was stirred for 2 hours. Yield: 21 mg, 53%; LC-MS tr 1.74 min; HPLC Purity: 96%; MS (ES+) m/z 342 (M+H); 1H NMR (400 MHz; DMSO): δ 6.7 (d, 1H), 7.4 (t, 1H), 7.45-7.55 (t, 2H), 7.70-7.80 (m, 5H), 7.9 (d, 1H), 8.05 (d, 1H), 8.10 (s, 1H), 8.30 (d, 1H), 8.50 (s, 1H), 12.55 (br. s, 1H)

Provenance & Evidence