1,2-Diaminocyclohexane, cis- → cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

HRID 659185

Reaction equation

HRID 659185 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[NH2:8].[F:9][C:10]([F:27])([F:26])[C:11]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[C:16]([O:24][CH3:25])[C:12]=1[C:13](O)=[O:14]>>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:13](=[O:14])[C:12]1[C:11]([C:10]([F:26])([F:27])[F:9])=[CH:19][C:18]([C:20]([F:21])([F:22])[F:23])=[CH:17][C:16]=1[O:24][CH3:25]

Participants

3

Reactant 2

HCID 3429171,2-Diaminocyclohexane, cis-HCID 27412872-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

Product 1

HCID 58062915cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Procedure

The title compound, yellow foam, MS: m/e=385.1 [(M+H)+], was prepared in accordance with the general method of intermediate G from cis-1,2-diaminocyclohexane and 2,4-bis(trifluoromethyl)-6-methoxybenzoic acid.

Sources & evidence

ORD record
ord-60523d04e48f47dcb09e94332e175576
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Linked notes

Loading…