1,2-Diaminocyclohexane, cis- → cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 659186

Reaction equation

HRID 659186 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[NH2:8].[CH3:9][O:10][C:11]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[C:16]([S:24][CH3:25])[C:12]=1[C:13](O)=[O:14]>>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:13](=[O:14])[C:12]1[C:16]([S:24][CH3:25])=[CH:17][C:18]([C:20]([F:23])([F:21])[F:22])=[CH:19][C:11]=1[O:10][CH3:9]

Participants

3

Reactant 2

HCID 3429171,2-Diaminocyclohexane, cis-HCID 591979212-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid2×

Product 1

HCID 58062914cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Procedure

The title compound, yellow foam, MS: m/e=385.1 [(M+H)+], was prepared in accordance with the general method of intermediate G from cis-1,2-diaminocyclohexane and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid (intermediate A).

Sources & evidence

ORD record
ord-9ca4834aae264adbabf030e6c04935cd
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Linked notes

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