Potassium Hydroxide → 2-Carboxy-5,6-dihydropyrrolo[1,2-c]quinazoline-6-propionic acid

Reaction equation

Cl.C([O:4][C:5](=[O:26])[CH2:6][CH2:7][N:8]1[C:17]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:11]2=[CH:18][C:19]([C:21]([O:23]CC)=[O:22])=[CH:20][N:10]2[CH2:9]1)C.[OH-].[K+]>CO.O>[C:21]([C:19]1[CH:18]=[C:11]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[N:8]([CH2:7][CH2:6][C:5]([OH:26])=[O:4])[CH2:9][N:10]2[CH:20]=1)([OH:23])=[O:22]

Participants

Procedure

A solution of the product of Example VI (2.75 g, 0.008 m) and KOH (4.0 g, 0.072 m) in MeOH (40 ml) and H2O (40 ml) was refluxed for 4 hr. The methanol was removed under vacuum and the resulting aqueous solution was acidified with HCl (10% aqueous). When the solution became acidic, a greenish solid formed. It was filtered and washed with H2O and dried, to yield 2.2 g of crude product. Crystallization from MeOH afforded the desired product; m.p. 234°-236°.