2-Cyclopropyl-4-(trifluoromethyl)benzoic acid → HCID 51000992, compound

HRID 659254

Reaction equation

HRID 659254 reaction equation
Cl.Cl.[N:3]1([C@H:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:14])[CH2:7][CH2:6][CH2:5][CH2:4]1.[CH:15]1([C:18]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:19]=2[C:20](O)=[O:21])[CH2:17][CH2:16]1>>[CH:15]1([C:18]2[CH:26]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:24]=[CH:23][C:19]=2[C:20]([NH:14][C@@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@@H:8]2[N:3]2[CH2:4][CH2:5][CH2:6][CH2:7]2)=[O:21])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acid2×HCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride2×

Product 1

HCID 51000992HCID 51000992, compound

Procedure

The title compound, white solid, MS: m/e=381.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (intermediate K).

Sources & evidence

ORD record
ord-538ca34b2e1b4b4ba88da42ab81e391a
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Linked notes

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