1,4-Dibromo-2-butanol → N-[(1RS,2SR)-2-(3-Hydroxy-pyrrolidin-1-yl)-cyclopentyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 659262

Reaction equation

HRID 659262 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[NH:7][C:8](=[O:23])[C:9]1[C:14]([S:15][CH3:16])=[CH:13][C:12]([C:17]([F:20])([F:19])[F:18])=[CH:11][C:10]=1[O:21][CH3:22].Br[CH2:25][CH:26]([OH:30])[CH2:27][CH2:28]Br>>[OH:30][CH:26]1[CH2:27][CH2:28][N:1]([CH:2]2[CH2:6][CH2:5][CH2:4][CH:3]2[NH:7][C:8](=[O:23])[C:9]2[C:14]([S:15][CH3:16])=[CH:13][C:12]([C:17]([F:19])([F:20])[F:18])=[CH:11][C:10]=2[O:21][CH3:22])[CH2:25]1

Participants

3

Reactant 2

HCID 295701,4-Dibromo-2-butanolHCID 66681196N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2×

Product 1

HCID 66682712N-[(1RS,2SR)-2-(3-Hydroxy-pyrrolidin-1-yl)-cyclopentyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Procedure

The title compound, colorless gum, MS: m/e=419.2 [(M+H)+], was prepared in accordance with the general method of example 10 from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and 1,4-dibromo-2-butanol.

Sources & evidence

ORD record
ord-5abd4a8454c44caf936c56b99252595e
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Linked notes

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