2-Methyl-4-(trifluoromethyl)benzoic acid → cis-2-Methyl-N-(2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

HRID 659268

Reaction equation

HRID 659268 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][C:13]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16]>>[CH3:12][C:13]1[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:19]=[CH:18][C:14]=1[C:15]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:16]

Participants

3

Reactant 2

HCID 222116582-Methyl-4-(trifluoromethyl)benzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 66681436cis-2-Methyl-N-(2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

Procedure

The title compound, yellow gum, MS: m/e=341.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methyl-4-trifluoromethyl-benzoic acid (CAS 23984-82-9).

Sources & evidence

ORD record
ord-af7cf134df8a43c4bb13298514395785
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Linked notes

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