2,4-Bis(trifluoromethyl)benzoic acid → N-(cis-2-Pyrrolidin-1-yl-cyclopentyl)-2,4-bis-trifluoromethyl-benzamide

HRID 659269Notes

Reaction equation

HRID 659269 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:12][C:13]([F:28])([F:27])[C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:15]=1[C:16](O)=[O:17]>>[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH:11][C:16](=[O:17])[C:15]2[CH:19]=[CH:20][C:21]([C:23]([F:24])([F:25])[F:26])=[CH:22][C:14]=2[C:13]([F:12])([F:27])[F:28])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 1417522,4-Bis(trifluoromethyl)benzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 58063002N-(cis-2-Pyrrolidin-1-yl-cyclopentyl)-2,4-bis-trifluoromethyl-benzamide

Procedure

The title compound, yellow solid, MS: m/e=395.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2,4-bis(trifluoromethyl)benzoic acid.

Sources & evidence

ORD record
ord-f0593e934cd8445bb4b2f84d53e42bba
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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