Diethyl Ether → 7-Chloro-1-methyllepidinium iodide

HRID 6602

Reaction equation

HRID 6602 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C[I:14].[CH2:15](OCC)C>CC#N>[I-:14].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N+:9]2[CH3:15])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 1704377-Chloro-4-methylquinoline

Product 1

HCID 220163717-Chloro-1-methyllepidinium iodide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A portion of the 7-chlorolepidine (80 mg) prepared as above was methylated by heating with CH3I (0.5 ml) in CH3CN (1 ml) at reflux for two hours. The mixture was treated with diethyl ether, followed by centrifugation, to give a yellow powder.

Workup

  1. temperatureat reflux for two hours
  2. customto give a yellow powder

Sources & evidence

ORD record
ord-6a873647e2b44ce99055068705e47796
Source dataset
uspto-grants-2006_08
Patent number
US07083982B2

Linked notes

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