HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Nitrophenyl)propionic acid | HCID 89244 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Aminohydratropic acid | HCID 43026 | — |
Reaction Steps
A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084484B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-fdc8fedb933d421686298bc443ce1c81 |
| Source note | uspto-grants-2011_12 |