Sodium Hydroxide → Ampicillin Sodium

HRID 66054Notes

Reaction equation

HRID 66054 reaction equation
[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].O.O.O.[OH-].[Na+:29]>O>[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([O-:23])=[O:22].[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23565Ampicillin Trihydrate

Product 1

HCID 23663979Ampicillin Sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 2.418 kg (6 mols) of ampicillin trihydrate in 15 liters of water was admixed with 300 ml of 2N sodium hydroxide, and the sodium ampicillin was isolated as a snow-white powder by lyophilization in the same manner and under the exact same conditions as in Example 1. The product was storage-stable and showed an active substance content of 91.5% in the microbiological test and 92.7% in the iodometric test.

Sources & evidence

ORD record
ord-0fed73dba5484d938aee81dfc0700611
Source dataset
uspto-grants-1978_12
Patent number
US04130558

Reaction notes

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