4-Bromo-3,5-dimethylphenol → 4'-Tert-butyl-2,6-dimethylbiphenyl-4-OL

HRID 660977

Reaction equation

HRID 660977 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:15]1[C:20]([CH3:21])=[CH:19][C:18]([OH:22])=[CH:17][C:16]=1[CH3:23]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:15]2[C:20]([CH3:21])=[CH:19][C:18]([OH:22])=[CH:17][C:16]=2[CH3:23])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 819704-Bromo-3,5-dimethylphenolHCID 27343204-tert-Butylphenylboronic acid

Product 1

HCID 533020184'-Tert-butyl-2,6-dimethylbiphenyl-4-OL

Procedure

This compound is made in a substantially similar manner as exemplified in Preparation 26 staring from 4-tert-butyl-phenyl boronic acid and 4-bromo-3,5-dimethyl phenol.

Sources & evidence

ORD record
ord-3f6a96cfc06e4686936b54910d77e5a1
Source dataset
uspto-grants-2011_12
Patent number
US08084489B2

Linked notes

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