2-Chloro-5-hydroxypyridine → 6-[4-(Trifluoromethyl)phenyl]pyridin-3-ol

Reaction equation

Cl[C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:9][C:10]([F:21])([F:20])[C:11]1[CH:16]=[CH:15][C:14]([C:2]2[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=2)=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 8198212-Chloro-5-hydroxypyridine

HCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 532295256-[4-(Trifluoromethyl)phenyl]pyridin-3-ol

Procedure

The titled compound is made in a manner substantially similar to Preparation 28 starting from the 6-chloro-pyridin-3-ol and 4-trifluoromethylphenyl boronic acid.

Sources & evidence

ORD record: ord-2e71052737394b5eb0cd136febf453cb
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08084489B2

Reaction notes

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