HCID 67498612, compound → HCID 67499593, compound

Reaction equation

[F:1][C:2]1([C:12]2[C:17]([CH3:18])=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.ClC1C(C2(F)CCC3(OCCO3)CC2)=NC=CC=1>>[F:1][C:2]1([C:12]2[C:17]([CH3:18])=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:11][CH2:10][C:5](=[O:6])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 67498612HCID 67498612, compound

HCID 67499172HCID 67499172, compound

Product 1

HCID 67499593HCID 67499593, compound

Procedure

The title compound was prepared using the procedure as described in Example 1C, except for substituting the product of Example 10B for the product of Example 1B. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.37 (d, J=4.4 Hz, 1 H) 7.66 (d, J=6.8 Hz, 1 H) 7.29 (dd, J=6.8, 4.4 Hz, 1 H), 2.54-2.93 (m, 4 H), 2.51 (s, 3 H), 2.18-2.46 (m, 4 H). MS (DCI) m/e 208 (M+H)+.

Sources & evidence

ORD record: ord-f02f987aa87f419abb1bc4e38cb728ad
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08084616B2

Reaction notes

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