4-Chlorobenzenesulfonyl chloride → 3-[2-(4-p-Chlorobenzenesulphonamido-1-piperidyl)ethyl]indole

HRID 66303

Reaction equation

HRID 66303 reaction equation
O.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([NH:2][CH:3]2[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)[CH2:5][CH2:4]2)(=[O:29])=[O:28])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 203843533-[2-(4-Aminopiperidyl)ethyl]indole, hydrate

Product 1

HCID 227548353-[2-(4-p-Chlorobenzenesulphonamido-1-piperidyl)ethyl]indole

Procedure

Using an analogous procedure to Example 1 3-[2-(4-amino-1-piperidyl)ethyl]indole monohydrate may be reacted with p-chlorobenzenesulphonyl chloride to give the title compound.

Sources & evidence

ORD record
ord-30676857f44a4739b11c8ae7667b5338
Source dataset
uspto-grants-1978_12
Patent number
US04131680

Linked notes

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