Nitric Acid → 6-Methyl-2-nitropyridin-3-ol
Reaction equation
[OH:1][C:2]1[CH:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>>[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1Participants
3
Conditions
- Temperature
- 6 °C
Procedure
To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.
Workup
- additionof ice cold concentrated sulfuric acid was added 10.9 g
- temperatureto warm to room temperature overnight
- stirringwith stirring
- customthe precipitate was collected
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-f3b692fa11714b5f803b8edbedaeef34
- Source dataset
- uspto-grants-1978_12
- Patent number
- US04131677
Reaction notes
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