HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 665Generated: October 23, 2026
2-Amino-5-bromo-4-methoxypyrimidine → 5-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-4-methoxypyrimidin-2-amine
https://huagongshe.com/en/reaction/665
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-5-bromo-4-methoxypyrimidine | HCID 45036937 | — |
| Reactant | 1-Fluoro-2-iodo-4-(trifluoromethyl)benzene | HCID 46735235 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-4-methoxypyrimidin-2-amine | HCID 106998904 | 0% |
Reaction Steps
To a microwave vial was added a mixture of 5-bromo-4-methoxypyrimidin-2-amine (0.513 g, 2.51 mmol), diacetoxypalladium (0.055 g, 0.245 mmol), tri(furan-2-yl)phosphine (0.126 g, 0.54 mmol), 1-fluoro-2-iodo-4-(trifluoromethyl)benzene (0.98 g, 3.38 mmol) and toluene (17 mL) under inert atmosphere. The reaction mixture was sealed and heated at 90 °C under 15h. The LCMS indicated no reaction ??? The sample discarded.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-f903bfa68e6e46fb8291b98645969acd |
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| Source note | 750 AstraZeneca ELN dataset |
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