2-[(4-Methylphenyl)amino]acetic acid → 2-(Cyclopentylamino)acetamide

HRID 66732

Reaction equation

HRID 66732 reaction equation
C[C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=O)=[CH:4]C=1.C1([NH:18]CC(O)=O)CCCC1>>[CH:5]1([NH:8][CH2:9][C:10]([NH2:18])=[O:12])[CH2:4][CH2:2][CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 2422362-[(4-Methylphenyl)amino]acetic acidHCID 3141012-(Cyclopentylamino)acetic acid

Product 1

HCID 167782572-(Cyclopentylamino)acetamide

Procedure

By replacing the p-methylphenylglycine employed in Procedure 14, Step A by an equivalent quantity of cyclopentylglycine, there is obtained cyclopentylglycinamide. Substituting this cyclopentylglycinamide for that employed in Procedure 13 and following the methods described in Steps A and B of Procedure 13, there is obtained in Step A 2-hydroxy-3-cyclopentylpyrazine and in Step B 2-chloro-3-cyclopentylpyrazine.

Sources & evidence

ORD record
ord-9f0c5ab3a7564326bd11ea5491ea0900
Source dataset
uspto-grants-1982_08
Patent number
US04343802

Linked notes

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