Morpholine → 5-Bromo-3-morpholinopyrazin-2-amine
Reaction equation
[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[NH2:1][C:2]1[C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1Participants
3
Procedure
2-Amino-3,5-dibromopyrazine is reacted with morpholine at 130° C. under pressure yielding 2-amino-3-morpholino-5-bromopyrazine.
Sources & evidence
- ORD record
- ord-e8c2f817bd9444889e8d1931f1312a4d
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04343802
Reaction notes
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