5-Bromo-3-morpholinopyrazin-2-amine → HCID 178517602, compound

HRID 66755

Reaction equation

N[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([Br:14])=[CH:4][N:3]=1.N([O-])=[O:16].[Na+]>>[OH:16][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([Br:14])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 167404415-Bromo-3-morpholinopyrazin-2-amine

HCID 23668193Sodium Nitrite

Product 1

HCID 178517602HCID 178517602, compound

Procedure

2-Amino-3-morpholino-5-bromopyrazine (see Preparation 92, Step A) is treated with sodium nitrite by the method described in Preparation 91, Step C, to give 2-hydroxy-3-morpholino-5-bromopyrazine.

Workup

customdescribed in Preparation 91, Step C

Sources & evidence

ORD record: ord-ff24d94000d64b99821ee2142652bf6d
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04343802

Linked notes

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