HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → 5-Benzamido-3-Trichloromethyl-1,2,4-Thiadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 5-Benzamido-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 12851601 | 85% |
Reaction Conditions
| Temperature | -10 °C |
|---|
Reaction Steps
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 14.1 g (0.1 mole) benzoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Upon cooling to -10° C., 13.7 g (85% yield) of pure product precipitated from the reaction mixture and was isolated by filtration; m.p. 190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04343945 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-1f492a9cadcf4eea91bdcf7b79a7d5e6 |
| Source note | uspto-grants-1982_08 |