4-Nitrophenyl chloroacetate → HCID 15754641, compound

HRID 67101

Reaction equation

HRID 67101 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:5](=[CH:7][C:8]3[N:9]=[C:10]([NH2:14])[S:11][C:12]=3[CH:13]=2)[N:6]=1.[Cl:15][CH2:16][C:17]([O:19]C1C=CC([N+]([O-])=O)=CC=1)=O>O1CCOCC1>[Cl:15][CH2:16][C:17]([NH:14][C:10]1[S:11][C:12]2[C:8](=[CH:7][C:5]3[N:6]=[C:2]([NH:1][C:17](=[O:19])[CH2:16][Cl:15])[S:3][C:4]=3[CH:13]=2)[N:9]=1)=[O:19]

Participants

4

Reactant 2

HCID 949174-Nitrophenyl chloroacetateHCID 844005ST076754

Product 1

HCID 15754641HCID 15754641, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture consisting of 222 mgm of 2,6-diamino-benzo[1,2-d:5,4-d']bisthiazole, 500 mgm of p-nitro-phenyl chloroacetate and 5 ml of dioxane were refluxed for 15 minutes. The reaction mixture was allowed to cool, and the crystalline substance which had separated out was filtered off, washed and dried. 350 mgm (93% of theory) of 2,6-bis-(chloroacetyl-amino)-benzo[1,2-d:5,4-d']bisthiazole, M.P. 330° C., were obtained.

Workup

  1. temperaturewere refluxed for 15 minutes
  2. temperatureto cool
  3. customthe crystalline substance which had separated out
  4. filtrationwas filtered off
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-d9a630a06f58499e841f82342f7220a8
Source dataset
uspto-grants-1982_08
Patent number
US04344946

Linked notes

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