Acetic Anhydride → HCID 15580461, compound
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][C:12]([OH:14])=O)=[CH:4][CH:3]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH:10]2[CH2:11][C:12](=[O:14])[O:17][C:16](=[O:18])[CH2:15]2)=[CH:6][CH:7]=1)(=[O:21])[CH3:20]Participants
3
Procedure
A solution of 3-[2-(4-hydroxyphenyl)ethyl]glutaric acid (600 mg) in acetic anhydride (15 ml) is heated in a bath at 120° C. for 2.0 hours. It is evaporated in vacuo and the residue is crystallized from dichloromethane-hexane to afford 495 mg of 3-[2-[4-(acetyloxy)phenyl]ethyl]glutaric anhydride, melting point 97°-99° C.
Workup
- customIt is evaporated in vacuo
- customthe residue is crystallized from dichloromethane-hexane
Sources & evidence
- ORD record
- ord-123826904ead48f0a7fe8e0060c900c6
- Source dataset
- uspto-grants-1982_08