cis-4-(3-Chlorophenyl)-but-3-enylamine → 4-(3-Chlorophenyl)butan-1-amine

HRID 6721

Reaction equation

HRID 6721 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]\[CH2:10][CH2:11][NH2:12])[CH:5]=[CH:6][CH:7]=1.[H][H]>CO.O.[Pt](=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 58679830cis-4-(3-Chlorophenyl)-but-3-enylamineHCID 178418361HCID 178418361, compound

Product 1

HCID 106550714-(3-Chlorophenyl)butan-1-amineYield 74.2%

Reagents, catalysts & solvents 2

HCID 11139377Platinum dioxide monohydrateCatalystHCID 887MethanolSolvent

Procedure

A solution of cis-4-(3-chlorophenyl)-but-3-enylamine (1.2 g) in 20 mL methanol was added to platinum(IV) oxide monohydrate (0.12 g). The mixture was stirred under 1 atm of hydrogen for 16 h. The mixture was filtered through celite, and the methanol was removed in vacuo to yield 0.9 g of 4-(3-chlorophenyl)-butylamine.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customthe methanol was removed in vacuo

Sources & evidence

ORD record
ord-6eda0c359052479e89b251fa31711b9d
Source dataset
uspto-grants-2006_08
Patent number
US07084154B2

Linked notes

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