(4-Phenyl-but-3-ynyl)-carbamic acid tert-butyl ester → 4-Phenyl-but-3-ynylamine

HRID 6724

Reaction equation

HRID 6724 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]#[C:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[C:12]1([C:11]#[C:10][CH2:9][CH2:8][NH2:7])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 23544319(4-Phenyl-but-3-ynyl)-carbamic acid tert-butyl ester

Product 1

HCID 156429914-Phenyl-but-3-ynylamine

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of (4-phenyl-but-3-ynyl)-carbamic acid tert-butyl ester (98 mg) was stirred for 0.5 h in 1:1 trifluoroacetic acid/dichloromethane (10 ml). The volatile materials were evaporated to give the crude 4-phenyl-but-3-ynylamine, which was used in subsequent transformations without further purification.

Workup

  1. customThe volatile materials were evaporated

Sources & evidence

ORD record
ord-20d2e46c1d1247a2976c93d528f9a3be
Source dataset
uspto-grants-2006_08
Patent number
US07084154B2

Linked notes

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