(4-Phenyl-but-3-ynyl)-carbamic acid tert-butyl ester → 4-Phenyl-but-3-ynylamine
Reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]#[C:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[C:12]1([C:11]#[C:10][CH2:9][CH2:8][NH2:7])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of (4-phenyl-but-3-ynyl)-carbamic acid tert-butyl ester (98 mg) was stirred for 0.5 h in 1:1 trifluoroacetic acid/dichloromethane (10 ml). The volatile materials were evaporated to give the crude 4-phenyl-but-3-ynylamine, which was used in subsequent transformations without further purification.
Workup
- customThe volatile materials were evaporated
Sources & evidence
- ORD record
- ord-20d2e46c1d1247a2976c93d528f9a3be
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07084154B2
Reaction notes
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