Reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]2[CH:13]=[N:14][C:15]([CH:16]=[N:17]O)=[C:5]2[C@@H:4]2[CH2:19][CH2:20][CH2:21][N:3]12>C(OC(=O)C)(=O)C>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]2[CH:13]=[N:14][C:15]([C:16]#[N:17])=[C:5]2[C@@H:4]2[CH2:19][CH2:20][CH2:21][N:3]12Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 5.24 g (18.5 mmol) of (S)-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxaldehyde-1-oxime in 50 ml of acetic acid anhydride is heated to boiling under reflux for 3 hours and subsequently evaporated in vacuo. The residue is taken up in chloroform, the solution is washed once with ca 30 ml of saturated sodium hydrogen carbonate solution and once with ca 30 ml of water, dried over magnesium sulphate and evaporated. After column chromatography and recrystallisation from ethyl acetate, there is obtained (S)-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carbonitrile of melting point 223°-225° C.
Workup
- temperatureunder reflux for 3 hours
- customsubsequently evaporated in vacuo
- washthe solution is washed once with ca 30 ml of saturated sodium hydrogen carbonate solution and once with ca 30 ml of water
- dry with materialdried over magnesium sulphate
- customevaporated
- customAfter column chromatography and recrystallisation from ethyl acetate
Sources & evidence
- ORD record
- ord-d6fe4e1954cb4e55ac409977c4865172
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04346030
Linked notes
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