Methanol → HCID 178418812, compound

Participants

Reaction Steps

A solution of 4-Imidazoleacetic acid, sodium salt, hydrate (compound ix, where R2 is H) (3.0 g, 18.1 mmol) in MeOH (50 ml) was cooled to about 0° C. and anhydrous HCl gas was bubbled into the mixture for about 15 minutes while maintaining reaction temperature below about 5° C. The reaction was stirred for about ½ hour at room temperature and then solvents were removed under reduced pressure to yield an oil which solidifies on standing. Mass spec 141.0 MH+, NMR (300 MHZ, DMSO-d6, 30° C.), 9.0–9.2 (1H, s), 7.4–7.6 (1H, s), 3.85–3.95 (2H, 3), 3.6–3.7 (3H, s).

Provenance & Evidence