Glyoxylic Acid → 4-Amino-3-sulfanyl-4,5-dihydro-1,2,4-triazin-5-one

HRID 67724

Reaction equation

HRID 67724 reaction equation
[C:1]([OH:5])(=O)[CH:2]=O.[NH2:6][NH:7][C:8]([NH:10][NH2:11])=[S:9]>O>[NH2:6][N:7]1[C:1](=[O:5])[CH:2]=[N:11][NH:10][C:8]1=[S:9]

Participants

4

Reactant 2

HCID 760Glyoxylic AcidHCID 2724189Thiocarbohydrazide

Product 1

HCID 130618424-Amino-3-sulfanyl-4,5-dihydro-1,2,4-triazin-5-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 22 parts glyoxylic acid in 22 parts water is slowly added to a hot, stirred solution of 32 parts thiocarbohydrazide in 350 parts water. The resulting mixture is refluxed until no further precipitate is formed. Upon cooling, essentially pure 4-amino-2,3-dihydro-3-thiono-as-triazin-5(4H)-one having a melting point of 211°-215° C. is obtained by filtration.

Workup

  1. temperatureThe resulting mixture is refluxed until no further precipitate
  2. customis formed
  3. temperatureUpon cooling

Sources & evidence

ORD record
ord-7c3be85c692f4eab9ae18d1027611f2f
Source dataset
uspto-grants-1982_08
Patent number
US04346220

Linked notes

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