1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7-[3-[(Cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

HRID 677401

Reaction equation

HRID 677401 reaction equation
[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([F:14])[c:11]([F:13])[c:12]12.[CH:20]1([NH:23][CH2:24][CH:25]2[CH2:26][NH:27][CH2:28][CH:29]2[F:30])[CH2:21][CH2:22]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([N:27]3[CH2:26][CH:25]([CH2:24][NH:23][CH:20]4[CH2:21][CH2:22]4)[CH:29]([F:30])[CH2:28]3)[c:11]([F:13])[c:12]12

Participants

3

Reactant 2

HCID 98351791-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 230620733-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4S)-(9CI)

Product 1

HCID 231256657-[3-[(Cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

Sources & evidence

ORD record
ord-f2ee2119fd414b3fb6883f20f98ca5ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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