Bromine → 2-Bromophenacyl Bromide

HRID 6776

Reaction equation

HRID 6776 reaction equation
[Br:1]Br.[Br:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Br:3])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 750602'-Bromoacetophenone

Product 1

HCID 27375222-Bromophenacyl Bromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (40.3 g, 0.25 mol) was added dropwise to a solution of 2′-Bromoacetophenone (50.0 g, 0.25 mol) in acetic acid (50 ml) over 1.5 hours at 15–20° C. The solution was then allowed to warm to room temperature and concentrated under reduced pressure to yield a crude product that was used without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-eba8a3d7c9cc40e19409ef56651f619b
Source dataset
uspto-grants-2006_08
Patent number
US07084135B1

Linked notes

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