Ethyl bromoacetate → 3-Methyl-4-oxo-2-phenyliminothiazolidine hydrobromide

HRID 67782

Reaction equation

HRID 67782 reaction equation
[Br:1]CC([O:5][CH2:6][CH3:7])=O.[CH3:8][NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[S:11]>CC(C)=O>[BrH:1].[CH3:8][N:9]1[C:6](=[O:5])[CH2:7][S:11][C:10]1=[N:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 6982941-Methyl-3-phenylthiourea

Product 1

HCID 205271953-Methyl-4-oxo-2-phenyliminothiazolidine hydrobromide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

10 g of ethyl bromoacetate and 9.95 g of 1-methyl-3-phenylthiourea in 150 ml of acetone are boiled for 1 hour under a reflux condenser. The reaction mixture is allowed to cool and the crystals are filtered off and washed with acetone. Melting point 212°-215° C.

Workup

  1. temperatureto cool
  2. filtrationthe crystals are filtered off
  3. washwashed with acetone

Sources & evidence

ORD record
ord-807f3c22deb64f20afe079763f77af03
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Linked notes

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