Sodium Hydroxide → N-Methyl-N'-phenylcarbodiimide

HRID 67784

Reaction equation

HRID 67784 reaction equation
Cl.[CH3:2][NH:3][C:4](Cl)=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[Na+]>C(Cl)(Cl)Cl>[CH3:2][N:3]=[C:4]=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178484191HCID 178484191, compound

Product 1

HCID 138144N-Methyl-N'-phenylcarbodiimide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A suspension of 2.05 g of N-methyl-N'-phenylchloroformamidine hydrochloride in 8 ml of chloroform is added, at 10°-12° C., to 6 g of 20% strength sodium hydroxide solution. The mixture is stirred for 10 minutes, the organic phase is separated off, the aqueous phase is extracted twice more with chloroform and the combined organic phases are dried over K2CO3. After filtering off the desiccant, the solution is subjected to further reaction without isolating the carbodiimide.

Workup

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted twice more with chloroform
  3. dry with materialthe combined organic phases are dried over K2CO3
  4. filtrationAfter filtering off the desiccant
  5. customthe solution is subjected to further reaction

Sources & evidence

ORD record
ord-f25a5706316a4c30a4802f436981a3a1
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Linked notes

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