3-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester → 3-[(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

HRID 678109

Reaction equation

HRID 678109 reaction equation
[CH3:1][O:2][C:3]([CH2:4][CH2:5][NH:6][C:7](=[O:8])[CH:9]1[CH2:10][N:11]([C:13]2=[N:17][C:16](=[O:18])[CH2:15][S:14]2)[CH2:12]1)=[O:19].[Cl:20][c:21]1[cH:22][c:23]([C:39]([F:40])([F:41])[F:42])[c:24]([CH2:25][n:26]2[n:27][cH:28][c:29]3[cH:30][c:31]([CH:35]=[O:36])[cH:32][cH:33][c:34]23)[cH:37][cH:38]1>>[CH3:1][O:2][C:3]([CH2:4][CH2:5][NH:6][C:7](=[O:8])[CH:9]1[CH2:10][N:11]([C:13]2=[N:17][C:16](=[O:18])[C:15](=[CH:35][c:31]3[cH:30][c:29]4[cH:28][n:27][n:26]([CH2:25][c:24]5[c:23]([C:39]([F:40])([F:41])[F:42])[cH:22][c:21]([Cl:20])[cH:38][cH:37]5)[c:34]4[cH:33][cH:32]3)[S:14]2)[CH2:12]1)=[O:19]

Participants

3

Reactant 2

HCID 672398093-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl esterHCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 672410533-[(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

Sources & evidence

ORD record
ord-d61d29a0ce7644ffbea7c50881207ff2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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