N-ethyl-3-methyl-6-nitroquinolin-2-amine → n2-Ethyl-3-methylquinoline-2.6-diamine
Reaction equation
[CH2:1]([NH:3][C:4]1[C:13]([CH3:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:15]([O-])=O)[CH:10]=2)[N:5]=1)[CH3:2]>CO.[Pt]=O>[CH2:1]([NH:3][C:4]1[C:13]([CH3:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:15])[CH:10]=2)[N:5]=1)[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The product (0.8 g) of Step B and platinum oxide on carbon (˜80 mg) was suspended in methanol. The resulting mixture was hydrogenated at 50 PSI for 1 h. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product, which was used without further purification.
Workup
- filtrationThe reaction mixture was filtered
- filtrationthrough filter aid
- customthe solvent removed under vacuum
- customto afford the product, which
- customwas used without further purification
Sources & evidence
- ORD record
- ord-bc1ae466ad6d421a8c6e6bc08d31abd8
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07084156B2
Reaction notes
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