N-ethyl-3-methyl-6-nitroquinolin-2-amine → n2-Ethyl-3-methylquinoline-2.6-diamine

HRID 6806

Reaction equation

HRID 6806 reaction equation
[CH2:1]([NH:3][C:4]1[C:13]([CH3:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:15]([O-])=O)[CH:10]=2)[N:5]=1)[CH3:2]>CO.[Pt]=O>[CH2:1]([NH:3][C:4]1[C:13]([CH3:14])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:15])[CH:10]=2)[N:5]=1)[CH3:2]

Participants

4

Reactant 1

HCID 22018880N-ethyl-3-methyl-6-nitroquinolin-2-amine

Product 1

HCID 85837566n2-Ethyl-3-methylquinoline-2.6-diamine

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

The product (0.8 g) of Step B and platinum oxide on carbon (˜80 mg) was suspended in methanol. The resulting mixture was hydrogenated at 50 PSI for 1 h. The reaction mixture was filtered through filter aid and the solvent removed under vacuum to afford the product, which was used without further purification.

Workup

  1. filtrationThe reaction mixture was filtered
  2. filtrationthrough filter aid
  3. customthe solvent removed under vacuum
  4. customto afford the product, which
  5. customwas used without further purification

Sources & evidence

ORD record
ord-bc1ae466ad6d421a8c6e6bc08d31abd8
Source dataset
uspto-grants-2006_08
Patent number
US07084156B2

Linked notes

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