5-Cyanopyridine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)phenyl]-5-cyanopyridine-2-carboxamide
Reaction equation
[C:18](#[N:19])[c:20]1[cH:21][cH:22][c:23]([C:26](=[O:27])[OH:28])[n:24][cH:25]1.[NH2:1][c:2]1[cH:3][c:4]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:5][cH:6][cH:7]1>>[NH:1]([c:2]1[cH:3][c:4]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:5][cH:6][cH:7]1)[C:26]([c:23]1[cH:22][cH:21][c:20]([C:18]#[N:19])[cH:25][n:24]1)=[O:27]Participants
3
Sources & evidence
- ORD record
- ord-c075a89482e94e2d99aa66f08ca1fa44
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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