Sodium Hydroxide → 3-(2,6-difluoropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[N:10](S(C3C=CC=CC=3)(=O)=O)[CH:9]=2)[CH:5]=[C:4]([F:26])[N:3]=1.[OH-].[Na+]>O1CCOCC1>[F:26][C:4]1[CH:5]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH:7]=[C:2]([F:1])[N:3]=1Participants
4
Procedure
A mixture of EXAMPLE 56A (8.01 g, 21.6 mmol) and 20% aqueous sodium hydroxide (12 mL, 21.6 mmol) in 1,4-dioxane (75 mL) was heated at 50° C. for 90 minutes. The mixture was concentrated and the residue triturated with water, filtered, and concentrated to give the title compound.
Workup
- concentrationThe mixture was concentrated
- customthe residue triturated with water
- filtrationfiltered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-60f99b14e4bf4a2289dea1a169b957a0
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08822446B2
Reaction notes
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