Dichloromethane → 6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([Cl:24])[c:5](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([S:16]([CH3:17])=[O:18])[n:14][cH:15]3)[n:19]([CH2:22][CH3:23])[c:20]2=[O:21])[cH:6][cH:7]1.[CH3:25][N:26]1[CH2:27][CH2:28][N:29]([c:32]2[cH:33][cH:34][c:35]([NH2:36])[cH:37][cH:38]2)[CH2:30][CH2:31]1.[Cl:39][CH2:40][Cl:41]>>[Br:1][c:2]1[cH:3][c:4]([Cl:24])[c:5](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([NH:36][c:35]4[cH:34][cH:33][c:32]([N:29]5[CH2:28][CH2:27][N:26]([CH3:25])[CH2:31][CH2:30]5)[cH:38][cH:37]4)[n:14][cH:15]3)[n:19]([CH2:22][CH3:23])[c:20]2=[O:21])[cH:6][cH:7]1