Dichloromethane → 4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,5-difluorophenol

Reaction equation

[B:24]([Br:25])([Br:26])[Br:27].[Cl:28][CH2:29][Cl:30].[F:1][c:2]1[c:3](-[c:11]2[n:12][n:13]([CH:21]([CH3:22])[CH3:23])[c:14]3[n:15][cH:16][n:17][c:18]([NH2:20])[c:19]23)[cH:4][c:5]([F:10])[c:6]([O:8][CH3:9])[cH:7]1>>[F:1][c:2]1[c:3](-[c:11]2[n:12][n:13]([CH:21]([CH3:22])[CH3:23])[c:14]3[n:15][cH:16][n:17][c:18]([NH2:20])[c:19]23)[cH:4][c:5]([F:10])[c:6]([OH:8])[cH:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 249051763-(2,5-difluoro-4-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 1359479744-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2,5-difluorophenol

Sources & evidence

ORD record: ord-93cf2ead8d034e31a25315c66d877f7b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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