HCID 178419031, compound → HCID 178418735, compound

HRID 6854

Reaction equation

HRID 6854 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 178419031HCID 178419031, compound

Product 1

HCID 178418735HCID 178418735, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H-NMR (MeOH-d4) δ 6.4–7 (m, 4H)

Workup

  1. filtrationThe reaction was filtered through a plug of celite
  2. concentrationthe filtrate concentrated in vacuo with toluene azeotroping

Sources & evidence

ORD record
ord-1c2f6a5a2ec34decaf8e5a51310a14b6
Source dataset
uspto-grants-2006_08
Patent number
US07084159B2

Linked notes

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