HCID 67163511, compound → N,N-bis[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide
Reaction equation
[CH3:1][Si:2]([CH3:51])([CH3:50])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[CH2:12][N:13]([CH2:36][C:37]1[N:38]([CH2:42][O:43][CH2:44][CH2:45][Si:46]([CH3:49])([CH3:48])[CH3:47])[CH:39]=[CH:40][N:41]=1)[C:14]([C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH2:22][N:21](C(OCC1C=CC=CC=1)=O)[CH2:20][CH2:19]2)=[O:15]>[C].[Pd]>[CH3:1][Si:2]([CH3:51])([CH3:50])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[CH2:12][N:13]([CH2:36][C:37]1[N:38]([CH2:42][O:43][CH2:44][CH2:45][Si:46]([CH3:49])([CH3:48])[CH3:47])[CH:39]=[CH:40][N:41]=1)[C:14]([C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH2:22][NH:21][CH2:20][CH2:19]2)=[O:15]Participants
3
Procedure
The same procedure as a series of reactions of Example 2 was carried out, except that the compound 12 was used in place of the compound 1 and 10% palladium carbon was used in place of 20% palladium hydroxide carbon, to obtain the title compound having the following physical properties.