5-amino-N-cyclopropyl-2,4-difluorobenzamide → N-Cyclopropyl-2,4-difluoro-5-{[2-(4-methyl-pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide

HRID 6875

Reaction equation

HRID 6875 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[S:10][C:11]([CH:14]=O)=[CH:12][N:13]=2)[CH:3]=1.[NH2:16][C:17]1[C:18]([F:30])=[CH:19][C:20]([F:29])=[C:21]([CH:28]=1)[C:22]([NH:24][CH:25]1[CH2:27][CH2:26]1)=[O:23]>>[CH:25]1([NH:24][C:22](=[O:23])[C:21]2[CH:28]=[C:17]([NH:16][CH2:14][C:11]3[S:10][C:9]([NH:8][C:4]4[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=4)=[N:13][CH:12]=3)[C:18]([F:30])=[CH:19][C:20]=2[F:29])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 219665075-amino-N-cyclopropyl-2,4-difluorobenzamideHCID 220190842-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde

Product 1

HCID 22019101N-Cyclopropyl-2,4-difluoro-5-{[2-(4-methyl-pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide

Procedure

2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde was treated with 5-amino-N-cyclopropyl-2,4-difluorobenzamide (for preparation see Example 18) in a manner similar to Example 1 to afford the title compound. LC/MS; (M+H)+=416.

Sources & evidence

ORD record
ord-137bd54ea5d047a4b72c7657d212dda8
Source dataset
uspto-grants-2006_08
Patent number
US07084160B2

Linked notes

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